Moderate traumatic brain injury promotes neural precursor proliferation without increasing neurogenesis in the adult hippocampus.

ABSTRACT: Traumatic brain injury (TBI) promotes neural stem/progenitor cell (NSC) proliferation in the adult hippocampus; however, it remains inconclusive whether proliferation of these cells results in newly generated mature neurons, leading to increased neurogenesis. When we traced the fates of proliferating cells labeled with bromodeoxyuridine (5-bromo-2-deoxyuridine, BrdU) we found that the number of BrdU-positive cells increased in the hippocampus of TBI mice compared to the sham control. However, double immunostaining to distinguish their cell types showed that most of these cells were glia, and that only a small subpopulation is newborn granular neurons. There was no significant difference with respect to neurogenesis in the adult hippocampus between the injured and the control mice. These re

SUBMITTER: Gao X 

PROVIDER: S-EPMC3755608 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature