A meta-analysis of the association between the CC chemokine ligand 5 (CCL5) -403 G>A gene polymorphism and tuberculosis susceptibility.

ABSTRACT:

Aim

Many case-control studies have been performed in the recent past to investigate the association between CCL5 -403 G>A (rs2107538) gene polymorphism and tuberculosis (TB) susceptibility in various ethnic groups. However, these studies have produced inconsistent and contradictory results. In the present study, meta-analysis was performed to assess the association between CCL5 -403 G>A polymorphism and TB risk.

Methodology

Quantitative synthesis was done for the published studies based upon association between CCL5 -403 G>A polymorphism and TB risk from PubMed (Medline), EMBASE web search. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous, heterozygous, dominant and recessive genetic models.

Results

A tota

SUBMITTER: Areeshi MY 

PROVIDER: S-EPMC3756059 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature