Identification of putative steroid receptor antagonists in bottled water: combining bioassays and high-resolution mass spectrometry.

ABSTRACT: Endocrine disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling and thereby adversely affecting human health. Recent reports provide evidence for the presence of EDCs in commercially available bottled water, including steroid receptor agonists and antagonists. However, since these findings are based on biological data the causative chemicals remain unidentified and, therefore, inaccessible for toxicological evaluation. Thus, the aim of this study is to assess the antiestrogenic and antiandrogenic activity of bottled water and to identify the causative steroid receptor antagonists. We evaluated the antiestrogenic and antiandrogenic activity of 18 bottled water products in reporter gene assays for human estrogen receptor alpha and androgen receptor. Using nont

SUBMITTER: Wagner M 

PROVIDER: S-EPMC3756062 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature