Augmentation of left ventricular wall thickness with alginate hydrogel implants improves left ventricular function and prevents progressive remodeling in dogs with chronic heart failure.

ABSTRACT:

Objectives

The study tested the hypothesis that augmentation of the left ventricular (LV) wall thickness with direct intramyocardial injections of alginate hydrogel implants (AHI) reduces LV cavity size, restores LV shape, and improves LV function in dogs with heart failure (HF).

Background

Progressive LV dysfunction, enlargement, and chamber sphericity are features of HF associated with increased mortality and morbidity.

Methods

Studies were performed in 14 dogs with HF produced by intracoronary microembolizations (LV ejection fraction [EF] <30%). Dogs were randomized to AHI treatment (n = 8) or to sham-operated control (n = 6). During an open-chest procedure, dogs received either intramyocardial injections of 0.25 to 0.35 ml of alginate hydrogel (Algisyl-LVR, LoneSt

SUBMITTER: Sabbah HN 

PROVIDER: S-EPMC3756288 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature