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Triple-helical recognition of RNA using 2-aminopyridine-modified PNA at physiologically relevant conditions.

ABSTRACT: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences.

SUBMITTER: Zengeya T 

PROVIDER: S-EPMC3756501 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Triple-helical recognition of RNA using 2-aminopyridine-modified PNA at physiologically relevant conditions.

Zengeya Thomas T   Gupta Pankaj P   Rozners Eriks E  

Angewandte Chemie (International ed. in English) 20121104 50

Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences. ...[more]

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