Blood-based gene expression signatures of infants and toddlers with autism.

ABSTRACT:

Objective

Autism spectrum disorders (ASDs) are highly heritable neurodevelopmental disorders that onset clinically during the first years of life. ASD risk biomarkers expressed early in life could significantly impact diagnosis and treatment, but no transcriptome-wide biomarker classifiers derived from fresh blood samples from children with autism have yet emerged.

Method

Using a community-based, prospective, longitudinal method, we identified 60 infants and toddlers at risk for ASDs (autistic disorder and pervasive developmental disorder), 34 at-risk for language delay, 17 at-risk for global developmental delay, and 68 typically developing comparison children. Diagnoses were confirmed via longitudinal follow-up. Each child's mRNA expression profile in peripheral blood monon

SUBMITTER: Glatt SJ 

PROVIDER: S-EPMC3756503 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature