Maternal smoking during pregnancy, prematurity and recurrent wheezing in early childhood.

ABSTRACT:

Background

Prenatal maternal smoking and prematurity independently affect wheezing and asthma in childhood.

Objective

We sought to evaluate the interactive effects of maternal smoking and prematurity upon the development of early childhood wheezing.

Methods

We evaluated 1,448 children with smoke exposure data from a prospective urban birth cohort in Boston. Maternal antenatal and postnatal exposure was determined from standardized questionnaires. Gestational age was assessed by the first day of the last menstrual period and early prenatal ultrasound (preterm < 37 weeks gestation). Wheezing episodes were determined from medical record extraction of well and ill/unscheduled visits. The primary outcome was recurrent wheezing, defined as ≥ 4 episodes of physician document

SUBMITTER: Robison RG 

PROVIDER: S-EPMC3756665 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature