Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood.

ABSTRACT:

Background

The relationship between the prenatal environment, maternal-fetal interaction, and allergic disease in the offspring remains understudied.

Objective

We sought to determine whether gestational diabetes (GDM) modifies the risk of early childhood atopic manifestations, including atopic dermatitis and allergen sensitization.

Methods

This study includes 680 children from the Boston Birth Cohort. Mother-child dyads were recruited at birth and followed prospectively to a mean age of 3.2 +/- 2.3 years, with study visits aligned with the pediatric primary care schedule. The primary outcomes were physician-diagnosed atopic dermatitis on standardized medical record abstraction and allergen sensitization based on ImmunoCAP to 7 common foods and 5 common aeroallergens (

SUBMITTER: Kumar R 

PROVIDER: S-EPMC3756674 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature