Designing functional metalloproteins: from structural to catalytic metal sites.

ABSTRACT: Metalloenzymes efficiently catalyze some of the most important and difficult reactions in nature. For many years, coordination chemists have effectively used small molecule models to understand these systems. More recently, protein design has been shown to be an effective approach for mimicking metal coordination environments. Since the first designed proteins were reported, much success has been seen for incorporating metal sites into proteins and attaining the desired coordination environment but until recently, this has been with a lack of significant catalytic activity. Now there are examples of designed metalloproteins that, although not yet reaching the activity of native enzymes, are considerably closer. In this review, we highlight work leading up to the design of a small metallopr

SUBMITTER: Zastrow ML 

PROVIDER: S-EPMC3756834 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature