Extending admixture mapping to nuclear pedigrees: application to sarcoidosis.

ABSTRACT: We describe statistical methods that extend the application of admixture mapping from unrelated individuals to nuclear pedigrees, allowing existing pedigree-based collections to be fully exploited. Computational challenges have been overcome by developing a fast algorithm that exploits the factorial structure of the underlying model of ancestry transitions. This has been implemented as an extension of the program ADMIXMAP. We demonstrate the application of the method to a study of sarcoidosis in African Americans that has previously been analyzed only as an admixture mapping study restricted to unrelated individuals. Although the ancestry signals detected in this pedigree analysis are generally similar to those detected in the earlier analysis of unrelated cases, we are able to extract mor

SUBMITTER: McKeigue PM 

PROVIDER: S-EPMC3756835 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature