Prevention of chronic kidney disease and subsequent effect on mortality: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To perform a systematic review of randomized controlled trials to determine whether prevention or slowing of progression of chronic kidney disease would translate into improved mortality, and if so, the attributable risk due to CKD itself on mortality.

Background

CKD is associated with increased mortality. This association is largely based on evidence from the observational studies and evidence from randomized controlled trials is lacking.

Methods

We searched Ovid, Medline and Embase for RCTs in which an intervention was given to prevent or slow the progression of CKD and mortality was reported as primary, secondary or adverse outcomes were eligible and selected. For the first phase, pooled relative risks for renal endpoints were assessed. For the second ph

SUBMITTER: Khan UA 

PROVIDER: S-EPMC3756976 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature