Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan.

ABSTRACT: Caloric/dietary restriction (CR/DR) can promote longevity and protect against age-associated disease across species. The molecular mechanisms coordinating food intake with health-promoting metabolism are thus of significant medical interest. We report that conserved Caenorhabditis elegans microRNA-80 (mir-80) is a major regulator of the DR state. mir-80 deletion confers system-wide healthy aging, including maintained cardiac-like and skeletal muscle-like function at advanced age, reduced accumulation of lipofuscin, and extended lifespan, coincident with induction of physiological features of DR. mir-80 expression is generally high under ad lib feeding and low under food limitation, with most striking food-sensitive expression changes in posterior intestine. The acetyltransferase transcript

SUBMITTER: Vora M 

PROVIDER: S-EPMC3757059 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature