How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation.

ABSTRACT: Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affect the expression and function of several genes due to drastic changes in the underlying gene regulatory network. However, we know little about critical gene regulators and their functional consequences on the pathogenesis of OS. Therefore, we aimed to determine microRNA and transcription factor (TF) co-regulatory networks in OS cell proliferation. Cell proliferation is an essential part in the pathogenesis of OS and deeper understanding of its regulation might help to identify potential therapeutic targets. Based on expression data of OS cell lines divided according to their proliferative activity, we obtained 12 proliferation-related microRNAs and corresponding target genes. Therewith, micr

SUBMITTER: Poos K 

PROVIDER: S-EPMC3757060 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature