Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro.

ABSTRACT: Many tissue engineering applications require the remodeling of a degradable scaffold either in vitro or in situ. Although inefficient remodeling or failure to fully remodel the temporary matrix can result in a poor clinical outcome, very few investigations have examined in detail, the interaction of regenerative cells with temporary scaffoldings. In a recent series of investigations, randomly oriented collagen gels were directly implanted into human corneal pockets and followed for 24 months. The resulting remodeling response exhibited a high degree of variability which likely reflects differing regenerative/synthetic capacity across patients. Given this variability, we hypothesize that a disorganized, degradable provisional scaffold could be disruptive to a uniform, organized reconstructi

SUBMITTER: Saeidi N 

PROVIDER: S-EPMC3757098 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature