Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.

ABSTRACT: Inflammation, characterized by the activation of both resident and infiltrated immune cells, is accompanied by increased production of oxidizing and nitrating species. Nitrogen dioxide, the proximal nitrating species formed under these conditions, reacts with unsaturated fatty acids to yield nitroalkene derivatives. These electrophilic products modulate protein function via post-translational modification of susceptible nucleophilic amino acids. Nitroalkenes react with Keap1 to instigate Nrf2 signaling, activate heat shock response gene expression, and inhibit NF-κB-mediated signaling, inducing net anti-inflammatory and tissue-protective metabolic responses. We report the purification and characterization of a NADPH-dependent liver enzyme that reduces the nitroalkene moiety of nitro-oleic

SUBMITTER: Vitturi DA 

PROVIDER: S-EPMC3757223 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature