Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.

ABSTRACT: Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility com

SUBMITTER: International Genetics of Ankylosing Spondylitis Consortium (IGAS) 

PROVIDER: S-EPMC3757343 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature