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Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.

ABSTRACT: The innate immune system is one of the first lines of defense against invading pathogens. Pathogens have, in turn, evolved different strategies to counteract these responses. Recent studies have illuminated how the hemorrhagic fever viruses Ebola and Lassa fever prevent host sensing of double-stranded RNA (dsRNA), a key hallmark of viral infection. The ebolavirus protein VP35 adopts a unique bimodal configuration to mask key cellular recognition sites on dsRNA. Conversely, the Lassa fever virus nucleoprotein actually digests the dsRNA signature. Collectively, these structural and functional studies shed new light on the mechanisms of pathogenesis of these viruses and provide new targets for therapeutic intervention.

SUBMITTER: Hastie KM

PROVIDER: S-EPMC3758253 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.

Hastie Kathryn M KM Bale Shridhar S Kimberlin Christopher R CR Saphire Erica Ollmann EO

Current opinion in virology 20120128 2

The innate immune system is one of the first lines of defense against invading pathogens. Pathogens have, in turn, evolved different strategies to counteract these responses. Recent studies have illuminated how the hemorrhagic fever viruses Ebola and Lassa fever prevent host sensing of double-stranded RNA (dsRNA), a key hallmark of viral infection. The ebolavirus protein VP35 adopts a unique bimodal configuration to mask key cellular recognition sites on dsRNA. Conversely, the Lassa fever virus ...[more]

PMID: 22482712

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