CD14 C-159T polymorphism and its association with chronic lung diseases: A pilot study on isocyanate exposed population of Central India.

ABSTRACT:

Context

CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to influence the cytokine profile and subsequent immunoglobulin E production in response to antigen/allergen contact in allergic phenotypes.

Aims

The present study was to investigate genetic polymorphism in CD14 gene - 159C/T, which may be one of the risk factor for increased prevalence of Chronic Lung Diseases in the Central India.

Settings and design

Survivors of Methyl isocyanates toxicity in Bhopal still suffering from various respiratory ailments were examined.

Materials and methods

Polymerase chain reaction-restriction fragment length polymorphism was performed to determine the polymorphism of C-159T.

Results<

SUBMITTER: Bose P 

PROVIDER: S-EPMC3758726 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature