Differentiation of human dental stem cells reveals a role for microRNA-218.

ABSTRACT:

Background

Regeneration of lost periodontium is the ultimate goal of periodontal therapy. Advances in tissue engineering have demonstrated the multilineage potential and plasticity of adult stem cells located in periodontal apparatus. However, it remains unclear how epigenetic mechanisms controlling signals determine tissue specification and cell lineage decisions. To date, no data are available on micro-RNA (miRNA) activity behind human-derived dental stem cells (DSCs).

Material and methods

In this study, we isolated periodontal ligament stem cells, dental pulp stem cells and gingival stem cells from extracted third molars; human bone marrow stem cells were used as a positive control. The expression of OCT4A and NANOG was confirmed in these undifferentiated cells. All cells

SUBMITTER: Gay I 

PROVIDER: S-EPMC3758777 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature