Health-related quality of life after catheter-directed thrombolysis for deep vein thrombosis: secondary outcomes of the randomised, non-blinded, parallel-group CaVenT study.

ABSTRACT:

Objectives

To investigate whether additional catheter-directed thrombolysis (CDT) improves long-term quality of life (QOL) compared with standard treatment with anticoagulation and compression stockings alone in patients with proximal deep vein thrombosis (DVT).

Design

Open-label randomised controlled trial.

Setting

19 Hospitals in the Norwegian southeastern health region.

Participants

Patients (18-75 years) with a high proximal DVT, symptoms <21 days and no increased risk of bleeding were eligible. 189 of 209 recruited patients completed 24 months of follow-up.

Interventions

Participants were randomised to additional CDT with alteplase for 1-4 days or to standard treatment only with 6 months of anticoagulation and 24 months of compression stockings.

SUBMITTER: Enden T 

PROVIDER: S-EPMC3758969 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature