A common variant in the adiponutrin gene influences liver enzyme values.

ABSTRACT:

Background

Two recent genome-wide association studies identified the liver expressed transmembrane protein adiponutrin to be associated with liver related phenotypes such as non-alcoholic fatty liver disease and liver function enzymes. These associations were not uniformly reported for various ethnicities. The aim of this study was to investigate a common non-synonymous variant within adiponutrin (rs738409, exon 3) with parameters of liver function in three independent West Eurasian study populations including a total of 4290 participants.

Methods

The study was performed in (1) the population based Bruneck Study (n=783), (2) the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk Study from Austria based on a healthy working population (n=1705), a

SUBMITTER: Kollerits B 

PROVIDER: S-EPMC3759243 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature