Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

ABSTRACT:

Background

VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans.

Methods

We did a genome-wide association study of discovery and replication cohorts. Samples from African-American adults (aged ≥18 years) who were taking a stable maintenance dose of warfarin were obtained at International Warfarin Pharmacogenetics Consortium (IWPC) sites and the University of Alabama at Birmingham (Birmingham, AL, USA). Patients enrolled at IWPC sites but who were not used for discovery made up the independent replication cohort. All participants were genotyped

SUBMITTER: Perera MA 

PROVIDER: S-EPMC3759580 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature