PEX16: a multifaceted regulator of peroxisome biogenesis.

ABSTRACT:

Peroxisomes are formed by two distinct pathways

the growth and fission of mature peroxisomes and de novo synthesis at the endoplasmic reticulum (ER). While many of the molecular mechanisms underlying these two pathways remain to be elucidated, it is generally accepted that their relative contribution to peroxisome formation may vary depending on the species, cell type and/or physiological status of the organism. One pertinent example of the apparent differences in the regulation of peroxisome biogenesis among evolutionarily diverse species is the involvement of the peroxin PEX16. In Yarrowia lipolytica, for instance, PEX16 is an intraperoxisomal peripheral membrane protein that participates in peroxisomal fission. By contrast, Human PEX16 is an integral membrane protein that is tho

SUBMITTER: Kim PK 

PROVIDER: S-EPMC3759792 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature