Vibrio cholerae ToxR downregulates virulence factor production in response to cyclo(Phe-Pro).

ABSTRACT:

Unlabelled

Vibrio cholerae is an aquatic organism that causes the severe acute diarrheal disease cholera. The ability of V. cholerae to cause disease is dependent upon the production of two critical virulence determinants, cholera toxin (CT) and the toxin-coregulated pilus (TCP). The expression of the genes that encode for CT and TCP production is under the control of a hierarchical regulatory system called the ToxR regulon, which functions to activate virulence gene expression in response to in vivo stimuli. Cyclic dipeptides have been found to be produced by numerous bacteria, yet their biological function remains unknown. V. cholerae has been shown to produce cyclo(Phe-Pro). Previous studies in our laboratory demonstrated that cyclo(Phe-Pro) inhibited V. cholerae virulence facto

SUBMITTER: Bina XR 

PROVIDER: S-EPMC3760244 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature