A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity.

ABSTRACT: Although comorbidity among complex diseases (e.g., drug dependence syndromes) is well documented, genetic variants contributing to the comorbidity are still largely unknown. The discovery of genetic variants and their interactions contributing to comorbidity will likely shed light on underlying pathophysiological and etiological processes, and promote effective treatments for comorbid conditions. For this reason, studies to discover genetic variants that foster the development of comorbidity represent high-priority research projects, as manifested in the behavioral genetics studies now underway. The yield from these studies can be enhanced by adopting novel statistical approaches, with the capacity of considering multiple genetic variants and possible interactions. For this purpose, we pro

SUBMITTER: Wen Y 

PROVIDER: S-EPMC3760410 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature