Alterations in gene expression in Caenorhabditis elegans associated with organophosphate pesticide intoxication and recovery.

ABSTRACT:

Background

The principal toxicity of acute organophosphate (OP) pesticide poisoning is the disruption of neurotransmission through inhibition of acetylcholinesterase (AChE). However, other mechanisms leading to persistent effects and neurodegeneration remain controversial and difficult to detect. Because Caenorhabditis elegans is relatively resistant to OP lethality--particularly through the inhibition of AChE--studies in this nematode provide an opportunity to observe alterations in global gene expression following OP exposure that cannot be readily observed in less resistant organisms.

Results

We exposed cultures of worms in axenic, defined medium to dichlorvos under three exposure protocols. In the first, worms were exposed continuously throughout the experiment. In the s

SUBMITTER: Lewis JA 

PROVIDER: S-EPMC3760450 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature