Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.

ABSTRACT: Coronary arteries bring blood flow to the heart muscle. Understanding the developmental program of the coronary arteries provides insights into the treatment of coronary artery diseases. Multiple sources have been described as contributing to coronary arteries including the proepicardium, sinus venosus (SV), and endocardium. However, the developmental origins of coronary vessels are still under intense study. We have produced a new genetic tool for studying coronary development, an AplnCreER mouse line, which expresses an inducible Cre recombinase specifically in developing coronary vessels. Quantitative analysis of coronary development and timed induction of AplnCreER fate tracing showed that the progenies of subepicardial endothelial cells (ECs) both invade the compact myocardium to form

SUBMITTER: Tian X 

PROVIDER: S-EPMC3760626 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature