Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder.

ABSTRACT:

Objective

Generalized anxiety disorder (GAD) typically begins during adolescence and can persist into adulthood. The pathophysiological mechanisms underlying this disorder remain unclear. Recent evidence from resting state functional magnetic resonance imaging (R-fMRI) studies in adults suggests disruptions in amygdala-based circuitry; the present study examines this issue in adolescents with GAD.

Method

Resting state fMRI scans were obtained from 15 adolescents with GAD and 20 adolescents without anxiety who were group matched on age, sex, scanner, and intelligence. Functional connectivity of the centromedial, basolateral, and superficial amygdala subdivisions was compared between groups. We also assessed the relationship between amygdala network dysfunction and anxiety sev

SUBMITTER: Roy AK 

PROVIDER: S-EPMC3760686 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature