Longitudinal trends in health-related quality of life in adults with cystic fibrosis.

ABSTRACT:

Background

Health-related quality-of-life (HRQOL) measures have been used as patient-reported outcomes in clinical trials in cystic fibrosis (CF), but there are limited data on HRQOL changes over time in adults with CF.

Methods

The Project on Adult Care in Cystic Fibrosis, a prospective, longitudinal panel study of 333 adults with CF at 10 CF centers in the United States, administered a disease-specific HRQOL measure, the Cystic Fibrosis Questionnaire-Revised (CFQ-R), seven times over 21 months. The CFQ-R assesses both physical and psychosocial domains of health. Growth curve regression models were developed for each CFQ-R domain, adjusting for demographic and clinical characteristics.

Results

Between 205 and 303 adults completed surveys (response rate, 70%-93%). Mean

SUBMITTER: Dill EJ 

PROVIDER: S-EPMC3760745 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature