Post-proliferative immature radial glial cells female-specifically express aromatase in the medaka optic tectum.

ABSTRACT: Aromatase, the key enzyme responsible for estrogen biosynthesis, is present in the brain of all vertebrates. Much evidence has accumulated that aromatase is highly and exclusively expressed in proliferating mature radial glial cells in the brain of teleost fish even in adulthood, unlike in other vertebrates. However, the physiological significance of this expression remains unknown. We recently found that aromatase is female-specifically expressed in the optic tectum of adult medaka fish. In the present study, we demonstrated that, contrary to the accepted view of the teleost brain, female-specific aromatase-expressing cells in the medaka optic tectum represent a transient subset of post-proliferative immature radial glial cells in the neural stem cell lineage. This finding led us to hypot

SUBMITTER: Takeuchi A 

PROVIDER: S-EPMC3760802 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature