Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study.

ABSTRACT: Candida albicans is responsible for a number of life-threatening infections and causes considerable morbidity and mortality in immunocompromised patients. Previous studies of C. albicans pathogenesis have suggested several steps must occur before virulent infection, including early adhesion, invasion, and late tissue damage. However, the mechanism that triggers C. albicans transformation from yeast to hyphae form during infection has yet to be fully elucidated. This study used a systems biology approach to investigate C. albicans infection in zebrafish. The surviving fish were sampled at different post-infection time points to obtain time-lapsed, genome-wide transcriptomic data from both organisms, which were accompanied with in sync histological analyses. Principal component analysis (PCA

SUBMITTER: Chen YY 

PROVIDER: S-EPMC3760836 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature