Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients.

ABSTRACT:

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The characteristics of nonalcoholic fatty liver disease (NAFLD) in elderly patients are unknown. Therefore, we aimed to examine the differences between elderly and nonelderly patients with NAFLD and to identify determinants of nonalcoholic steatohepatitis (NASH) and advanced fibrosis (bridging fibrosis or cirrhosis) in elderly patients. This is a cross-sectional analysis of adult participants who were prospectively enrolled in the NASH Clinical Research Network studies. Participants were included based on availability of the centrally reviewed liver histology data within 1 year of enrollment, resulting in 61 elderly (age ≥65 years) and 735 nonelderly (18-64 years) participants. The main outcomes were the presence of NASH and advanced fibrosis. Compared to nonelderly pati

SUBMITTER: Noureddin M 

PROVIDER: S-EPMC3760979 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature