Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

ABSTRACT:

Background

Substantial interindividual variability exists in the disease trajectories of Alzheimer's disease (AD) patients. Some decline rapidly whereas others decline slowly, and there are no known explanations for this variability. We describe the first genome-wide association study to examine rate of cognitive decline in a sample of AD patients with longitudinal measures of cognition.

Methods

The discovery sample was 303 AD cases recruited in the Alzheimer's Disease Neuroimaging Initiative and the replication sample was 323 AD cases from the Religious Orders Study and Rush Memory and Aging Project. In the discovery sample, Alzheimer's Disease Assessment Scale-cognitive subscale responses were tested for association with genome-wide single-nucleotide polymorphism (SNP) dat

SUBMITTER: Sherva R 

PROVIDER: S-EPMC3760995 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature