Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.

ABSTRACT: Zymogen granule (ZG) formation in acinar cells involves zymogen cargo sorting from trans-Golgi into immature secretory granules (ISGs). ISG maturation progresses by removal of lysosomal membrane and select content proteins, which enter endosomal intermediates prior to their apical exocytosis. Constitutive and stimulated secretion through this mechanism is termed the constitutive-like and minor-regulated pathways, respectively. However, the molecular components that control membrane trafficking within these endosomal compartments are largely unknown. We show that tumor protein D52 is highly expressed in endosomal compartments following pancreatic acinar cell stimulation and regulates apical exocytosis of an apically directed endolysosomal compartment. Secretion from the endolysosomal compar

SUBMITTER: Messenger SW 

PROVIDER: S-EPMC3761242 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature