Robust identification of local adaptation from allele frequencies.

ABSTRACT: Comparing allele frequencies among populations that differ in environment has long been a tool for detecting loci involved in local adaptation. However, such analyses are complicated by an imperfect knowledge of population allele frequencies and neutral correlations of allele frequencies among populations due to shared population history and gene flow. Here we develop a set of methods to robustly test for unusual allele frequency patterns and correlations between environmental variables and allele frequencies while accounting for these complications based on a Bayesian model previously implemented in the software Bayenv. Using this model, we calculate a set of "standardized allele frequencies" that allows investigators to apply tests of their choice to multiple populations while accounting

SUBMITTER: Gunther T 

PROVIDER: S-EPMC3761302 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature