Building multidimensional biomarker views of type 2 diabetes on the basis of protein microheterogeneity.

ABSTRACT:

Background

In 2008, the US Food and Drug Administration (FDA) issued a Guidance for Industry statement formally recognizing (during drug development) the conjoined nature of type 2 diabetes (T2D) and cardiovascular disease (CVD), which has precipitated an urgent need for panels of markers (and means of analysis) that are able to differentiate subtypes of CVD in the context of T2D. Here, we explore the possibility of creating such panels using the working hypothesis that proteins, in addition to carrying time-cumulative marks of hyperglycemia (e.g., protein glycation in the form of Hb A(₁c)), may carry analogous information with regard to systemic oxidative stress and aberrant enzymatic signaling related to underlying pathobiologies involved in T2D and/or CVD.

Methods

We used

SUBMITTER: Borges CR 

PROVIDER: S-EPMC3761388 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature