Acute on-chip HIV detection through label-free electrical sensing of viral nano-lysate.

ABSTRACT: Development of portable biosensors has broad applications in environmental monitoring, clinical diagnosis, public health, and homeland security. There is an unmet need for pathogen detection at the point-of-care (POC) using a fast, sensitive, inexpensive, and easy-to-use method that does not require complex infrastructure and well-trained technicians. For instance, detection of Human Immunodeficiency Virus (HIV-1) at acute infection stage has been challenging, since current antibody-based POC technologies are not effective due to low concentration of antibodies. In this study, we demonstrated for the first time a label-free electrical sensing method that can detect lysed viruses, i.e. viral nano-lysate, through impedance analysis, offering an alternative technology to the antibody-based me

SUBMITTER: Shafiee H 

PROVIDER: S-EPMC3761882 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature