Transcriptome sequencing reveals the character of incomplete dosage compensation across multiple tissues in flycatchers.

ABSTRACT: Sex chromosome divergence, which follows the cessation of recombination and degeneration of the sex-limited chromosome, can cause a reduction in expression level for sex-linked genes in the heterozygous sex, unless some mechanisms of dosage compensation develops to counter the reduction in gene dose. Because large-scale perturbations in expression levels arising from changes in gene dose might have strong deleterious effects, the evolutionary response should be strong. However, in birds and in at least some other female heterogametic organisms, wholesale sex chromosome dosage compensation does not seem to occur. Using RNA-seq of multiple tissues and individuals, we investigated male and female expression levels of Z-linked and autosomal genes in the collared flycatcher, a bird for which a

SUBMITTER: Uebbing S 

PROVIDER: S-EPMC3762201 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature