Ontology highlight
ABSTRACT:
SUBMITTER: Bian S
PROVIDER: S-EPMC3762321 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Cell reports 20130425 5
During development of the embryonic neocortex, tightly regulated expansion of neural stem cells (NSCs) and their transition to intermediate progenitors (IPs) are critical for normal cortical formation and function. Molecular mechanisms that regulate NSC expansion and transition remain unclear. Here, we demonstrate that the microRNA (miRNA) miR-17-92 cluster is required for maintaining proper populations of cortical radial glial cells (RGCs) and IPs through repression of Pten and Tbr2 protein. Kn ...[more]