Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus.

ABSTRACT:

Objective

This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C → T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM).

Research design and methods

Several research databases were systematically searched for studies examining the genotype at the rs1801133 polymorphism in healthy control individuals and individuals with type 2 DM. Genotype frequency data were examined across all studies and across subsets of studies according to ethnicity and presence of serious DM-related complications. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

A total of 4855 individuals with type 2 DM and 5242 healthy controls f

SUBMITTER: Zhong JH 

PROVIDER: S-EPMC3762795 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature