Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.

ABSTRACT:

Purpose

BRAF mutations are found in a subset of non-small cell lung cancers (NSCLC). We examined the clinical characteristics and treatment outcomes of patients with NSCLC harboring BRAF mutations.

Experimental design

Using DNA sequencing, we successfully screened 883 patients with NSCLC for BRAF mutations between July 1, 2009 and July 16, 2012. Baseline characteristics and treatment outcomes were compared between patients with and without BRAF mutations. Wild-type controls consisted of patients with NSCLC without a somatic alteration in BRAF, KRAS, EGFR, and ALK. In vitro studies assessed the biologic properties of selected non-V600E BRAF mutations identified from patients with NSCLC.

Results

Of 883 tumors screened, 36 (4%) harbored BRAF mutations (V600E, 18; non-V60

SUBMITTER: Cardarella S 

PROVIDER: S-EPMC3762878 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature