COX-2-765G>C polymorphism increases the risk of cancer: a meta-analysis.

ABSTRACT:

Background

Chronic inflammation has been regarded as an important mechanism in carcinogenesis. Inflammation-associated genetic variants have been highly associated with cancer risk. Polymorphisms in the gene cyclooxygenase-2 (COX-2), a pro-inflammation factor, have been suggested to alter the risk of multiple tumors, but the findings of various studies are not consistent.

Methods

A literature search through February 2013 was performed using PubMed, EMBASE, and CNKI databases. We used odds ratios (ORs) with confidence intervals (CIs) of 95% to assess the strength of the association between the COX-2-765G>C polymorphism and cancer risk in a random-effect model. We also assessed heterogeneity and publication bias.

Results

In total, 65 articles with 29,487 cancer cases an

SUBMITTER: Wang XF 

PROVIDER: S-EPMC3762903 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature