XM: association testing on the X-chromosome in case-control samples with related individuals.

ABSTRACT: Genetic variants on the X-chromosome could potentially play an important role in some complex traits. However, development of methods for detecting association with X-linked markers has lagged behind that for autosomal markers. We propose methods for case-control association testing with X-chromosome markers in samples with related individuals. Our method, XM, appropriately adjusts for both correlation among relatives and male-female allele copy number differences. Features of XM include: (1) it is applicable to and computationally feasible for completely general combinations of family and case-control designs; (2) it allows for both unaffected controls and controls of unknown phenotype to be included in the same analysis; (3) it can incorporate phenotype information on relatives with miss

SUBMITTER: Thornton T 

PROVIDER: S-EPMC3762984 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature