The methionine sulfoxide reduction system: selenium utilization and methionine sulfoxide reductase enzymes and their functions.

ABSTRACT:

Significance

Selenium is utilized in the methionine sulfoxide reduction system that occurs in most organisms. Methionine sulfoxide reductases (Msrs), MsrA and MsrB, are the enzymes responsible for this system. Msrs repair oxidatively damaged proteins, protect against oxidative stress, and regulate protein function, and have also been implicated in the aging process. Selenoprotein forms of Msrs containing selenocysteine (Sec) at the catalytic site are found in bacteria, algae, and animals.

Recent advances

A selenoprotein MsrB1 knockout mouse has been developed. Significant progress in the biochemistry of Msrs has been made, which includes findings of a novel reducing system for Msrs and of an interesting reason for the use of Sec in the Msr system. The effects of mammalian Ms

SUBMITTER: Kim HY 

PROVIDER: S-EPMC3763222 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature