Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis.

ABSTRACT: Chromatin structure and function are for a large part determined by the six members of the structural maintenance of chromosomes (SMC) protein family, which form three heterodimeric complexes: Smc1/3 (cohesin), Smc2/4 (condensin) and Smc5/6. Each complex has distinct and important roles in chromatin dynamics, gene expression and differentiation. In yeast and Drosophila, Smc6 is involved in recombinational repair, restarting collapsed replication forks and prevention of recombination in repetitive sequences such as rDNA and pericentromeric heterochromatin. Although such DNA damage control mechanisms, as well as highly dynamic changes in chromatin composition and function, are essential for gametogenesis, knowledge on Smc6 function in mammalian systems is limited. We therefore have investiga

SUBMITTER: Verver DE 

PROVIDER: S-EPMC3763431 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature