A dioxane template for highly selective epoxy alcohol cyclizations.

ABSTRACT: Ladder polyether natural products are a class of natural products denoted by their high functional-group density and large number of well-defined stereocenters. They comprise the toxic component of harmful algal blooms (HABs), having significant negative economic and environmental ramifications. However, their mode of action, namely blocking various cellular ion channels, also denotes their promise as potential anticancer agents. Understanding their potential mode of biosynthesis will not only help with developing ways to limit the damage of HABs, but would also facilitate the synthesis of a range of analogs with interesting biological activity. 1,3-Dioxan-5-ol substrates display remarkable 'enhanced template effects' in water-promoted epoxide cyclization processes en route to the synthesi

SUBMITTER: Mousseau JJ 

PROVIDER: S-EPMC3763493 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature