Novel approach for selecting the best predictor for identifying the binding sites in DNA binding proteins.

ABSTRACT: Protein-DNA complexes play vital roles in many cellular processes by the interactions of amino acids with DNA. Several computational methods have been developed for predicting the interacting residues in DNA-binding proteins using sequence and/or structural information. These methods showed different levels of accuracies, which may depend on the choice of data sets used in training, the feature sets selected for developing a predictive model, the ability of the models to capture information useful for prediction or a combination of these factors. In many cases, different methods are likely to produce similar results, whereas in others, the predictors may return contradictory predictions. In this situation, a priori estimates of prediction performance applicable to the system being investig

SUBMITTER: Nagarajan R 

PROVIDER: S-EPMC3763535 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature