Arpeggio: harmonic compression of ChIP-seq data reveals protein-chromatin interaction signatures.

ABSTRACT: Researchers generating new genome-wide data in an exploratory sequencing study can gain biological insights by comparing their data with well-annotated data sets possessing similar genomic patterns. Data compression techniques are needed for efficient comparisons of a new genomic experiment with large repositories of publicly available profiles. Furthermore, data representations that allow comparisons of genomic signals from different platforms and across species enhance our ability to leverage these large repositories. Here, we present a signal processing approach that characterizes protein-chromatin interaction patterns at length scales of several kilobases. This allows us to efficiently compare numerous chromatin-immunoprecipitation sequencing (ChIP-seq) data sets consisting of many typ

SUBMITTER: Stanton KP 

PROVIDER: S-EPMC3763565 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature