Genetics in diabetic retinopathy: current concepts and new insights.

ABSTRACT: There is emerging evidence which indicates the essential role of genetic factors in the development of diabetic retinopathy (DR). In this regard it should be highlighted that genetic factors account for 25-50% of the risk of developing DR. Therefore, the use of genetic analysis to identify those diabetic patients most prone to developing DR might be useful in designing a more individualized treatment. In this regard, there are three main research strategies: candidate gene studies, linkage studies and Genome-Wide Association Studies (GWAS). In the candidate gene approach, several genes encoding proteins closely related to DR development have been analyzed. The linkage studies analyze shared alleles among family members with DR under the assumption that these predispose to a more aggressive

SUBMITTER: Simo-Servat O 

PROVIDER: S-EPMC3763680 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature