Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis.

ABSTRACT:

Background

Genetic polymorphisms associated with common aetiologically complex diseases have recently been identified through genome-wide association studies. Direct-to-consumer genetic testing for such polymorphisms, with provision of absolute genetic risk estimates, is marketed by several commercial companies. Polymorphisms associated with atrial fibrillation (AF) have shown relatively large risk estimates, but the robustness of such estimates across populations and study designs has not been investigated.

Design

A systematic literature review with meta-analysis and assessment of between-study heterogeneity was carried out for single-nucleotide polymorphisms (SNPs) in the six genetic regions associated with AF in genome-wide or candidate gene studies.

Results

Data w

SUBMITTER: Smith JG 

PROVIDER: S-EPMC3763745 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature